Shi et al Diet Induced Endothelial Senescence in Baboons 1 Title page Title: Endothelial Senescence after High Cholesterol High Fat Diet Challenge in Baboons Short title: Shi et al Diet Induced Endothelial Senescence in Baboons
نویسندگان
چکیده
Department of Genetics, Department of Physiology and Medicine, Southwest Foundation for Biomedical Research; Southwest National Primate Research Center, San Antonio, Texas; Cardiothoracic Research Laboratory, Texas Heart Institute, St. Luke’s Episcopal Hospital, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas; 5 Department of Medicine/Division of Hematology, University of Texas Health Science Center, San Antonio, Texas
منابع مشابه
Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons.
Increasing evidence indicates that replicative senescence and premature endothelial senescence could contribute to endothelial dysfunction. This study aims at testing the hypothesis that a high-fat diet may lead to premature vascular endothelial senescence in a nonhuman primate model. We isolated endothelial cells from left and right femoral arteries in 10 baboons before and after a 7-wk high-f...
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BACKGROUND Endothelial dysfunction signals the initiation and progression of atherosclerosis. Elevated LDL-cholesterol concentrations have been suggested to induce endothelial dysfunction, but direct in vivo evidence for the relation is still lacking. OBJECTIVE We examined the hypothesis that a high-cholesterol, high-fat (HCHF) diet can directly cause endothelial dysfunction in vivo. DESIGN...
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Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney failure and visual impairment. Alpha-mangostin is a xanthone found in mangosteen fruit with protective effects in met...
متن کاملDisturbed flow promotes endothelial senescence via a p53-dependent pathway.
OBJECTIVE Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms that link disturbed flow-generated mechanical forces with arterial injury are uncertain. To illuminate them, we investigated the effects o...
متن کاملEndothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model.
BACKGROUND Because of global aging, the prevalence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains incompletely understood, endothelial inflammation is stated to play a central role. Cellular senescence is a process of cellular growth arrest linked with aging and inflammation. We used mice with accelerated aging to investigate ...
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تاریخ انتشار 2007